James Parkinson and Aloïs Alzheimer interview Jean-Bernard Fourtillan (1st part)

Letter from Pr Henri Joyeux no 142

In this letter, to facilitate understanding, we have devised a dialogue between James Parkinson and Alois Alzheimer. They interview Professor Jean-Bernard Fourtillan who discovered the sleep hormone, as well as sleep-wake regulation.
After the detailed presentation, by James Parkinson and Alois Alzheimer themselves, of the diseases named after them, here is a first fictional interview conducted by James and Alois. They talk to Professor Jean-Bernard Fourtillan, who discovered the sleep hormone and the sleep-wake regulation.
First interview
These two neurodegenerative diseases share the same cause which can affect different regions of the brain: the secretions of the 3 pineal hormones, Melatonin, 6-Methoxyharmalan and Valentonin are insufficient.
Pr Jean-Bernard Fourtillan explains in detail the action of the 3 hormones produced by the small pineal gland at the centre of the brain, also known as epiphysis. Discharged into the blood stream during the night, they are distributed throughout the body and make their way to their sites of action. Melatonin protects all cells, more specifically the nerve cells (neurons), by reducing oxygenated free radicals, which prevents their destruction via radical oxidation processes.
The other 2 pineal hormones, Valentonin (VLT) and 6-Methoxyharmalan (6-MH), modulate the responses of 2 types of specific receptors:
– the receptors of the neurotransmitters located on synapses, junction points between the neurons.  They amplify (VLT) or reduce (6-MH) the transmission of nerve impulses in these neurons;
– and the hormone receptors (receptors of liberins or stimulines) located on the endocrine glands (hypophysis, etc.). VLT reduces hormonal secretions during the night, unlike 6-MH, which reduces them during the day.
Thanks to their competing actions, in waking or sleeping mode, VLT and 6-MH totally regulate the life of our body 24 hours a day.
The discovery of these regulation mechanisms helps explain the effectiveness of the substitution treatment which provides the 3 hormones of the sleep-wake regulation, in the prevention and treatment of neurological disorders.

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Aloïs Alzheimer’s incredible letter about the discovery of Sleep-Wake regulation

Letter from Pr Henri Joyeux no 138

In his letter to all those affected by Alzheimer’s disease, Pr Henri Joyeux gets the father of the disease himself to talk. How did he discover and describe it? Why is it named after him? Why are all the treatments proposed to patients, even at the onset of the disease, completely ineffective? The recent controversy about reimbursements is significant: experts are asking to put a stop to the reimbursement of useless and costly drugs, and the French Minister of health wants to maintain them to avoid losing the votes of the elderly.

Alois Alzheimer presents the discovery made in France by Pr Jean-Bernard Fourtillan, a professor of medicinal chemistry. It relates to the regulation of the Sleep-Wake system, which is the responsibility of the pineal gland, aka epiphysis. The deregulation of this system causes all the disorders of the disease. Incredible therapeutic prospects for tens of millions of people worldwide.

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I, your pineal gland aka epiphysis

Letter from Pr Henri Joyeux no 137

In this original letter, it is the pineal gland which is talking to you, informing you of its location, shape and dimensions. The most important thing is of course its role and the fundamental discovery that it is the source of Sleep-Wake regulation in human beings.

You will comprehend what the actual purpose of Melatonin is, while recognising the wake and cognition hormone and, more importantly, the sleep hormone, aka Valentonin. This discovery was obviously protected by patents, after which it was presented on 2 December 2015 to the National Pharmaceutical Academy, before an audience of scientists. This small pineal gland has fascinated for centuries. Outside the brain’s protective barrier known as the “blood-brain barrier”, the hormones it produces are distributed throughout the body according to its needs. This tiny gland is therefore the supreme conductor of hormonal symphonies.

This discovery has tremendous therapeutic implications which are currently being identified. It will be instrumental in preventing and overcoming neuro-degenerative diseases, particularly Alzheimer’s and Parkinson’s disease, as long as there are no definitive and irreversible lesions.

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